| Bedangshu Saikia, Himanshu Aneja, Ayush Manchanda, Rittick Patowary*, Bhupen Barman**
Dept of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi-110054. India.
* MIOT Hospitals, Chennai-600089. India
** Assistant Professor, Dept of Medicine, Lady Hardinge Medical College and Associated Hospitals, New Delhi-110001. India
Corresponding Author: Dr Bedangshu Saikia,
Dept of Pediatrics, St Stephens Hospital, Tis Hazari, Delhi-110054, India. E-mail: bedangshu@gmail.com
Abstract
Carbamazepine is a commonly used drug. It is important to be aware of common as well as uncommon adverse effects of commonly used drugs. Apart from the neurological side-effects, haematological side-effects in form of aplastic anemia and agranulocytosis are well-documented. We report a case of pure red cell aplasia (PRCA) following institution of carbamazepine therapy for seizures in a 7-year old girl. PRCA reverted on discontinuation of carbamazepine. PRCA is an uncommon complication of carbamazepine therapy, this being the fifth only case in world literature. It is recommended that blood counts be periodically monitored in patients on carbamazepine.
Keywords: Hematologic diseases; pure red-cell aplasia; antiepileptics, carbamazepine
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